The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene

被引：31

作者：

Olsson, PG

Lohning, C

Horsley, S

Kearney, L

Harris, PC

Frischauf, AM

机构：

[1] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND

[2] JOHN RADCLIFFE HOSP,MRC,MOLEC HAEMATOL UNIT,INST MOLEC MED,OXFORD OX3 9DU,ENGLAND

来源：

GENOMICS | 1996年 / 34卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1006/geno.1996.0273

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The mouse homologue of the polycystic kidney disease 1 gene (PKD1) was mapped to chromosome 17 using somatic cell hybrids, B x D recombinant inbred strains, and FISH. The gene is located within a previously defined conserved synteny group that includes the mouse homologue of tuberous sclerosis 2 (TSCS) and is linked to the alpha globin pseudogene Hba-ps4. Although the human genome contains multiple copies of genes related to PKD1, there is no evidence for more than one copy in the mouse genome. Like their human counterparts, the mouse Tsc2 and Pkd1 genes are arranged in a tail-to-tail orientation with a distance of only 63 bp between the polyadenylation signals of the two genes. (C) 1996 Academic Press, Inc.

引用

页码：233 / 235

页数：3

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