Relationship between adiponectin, obesity and insulin resistance

被引:111
作者
Balsan, Guilherme Ardenghi [1 ,2 ]
da Costa Vieira, Jose Luiz
de Oliveira, Aline Marcadenti [3 ,4 ]
Portal, Vera Lucia [5 ]
机构
[1] Reg Integrated Univ Upper Uruguai & Missions, Rio De Janeiro, RS, Brazil
[2] Cardiol Univ Fdn RS FUC RS, Hlth Sci Cardiol, Porto Alegre, RS, Brazil
[3] FUC RS, Inst Cardiol, Med Residency Outpatient Clin, Hlth Sci Cardiol, Porto Alegre, RS, Brazil
[4] FUC RS, Inst Cardiol, Grad Program, Cardiovasc Sci Ufrgs, Porto Alegre, RS, Brazil
[5] FUC RS, Grad Program Hlth Sci, Hlth Sci Cardiol, Porto Alegre, RS, Brazil
来源
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA | 2015年 / 61卷 / 01期
关键词
obesity; adiponectin; insulin resistance; FATTY-ACID OXIDATION; SKELETAL-MUSCLE; ENDOTHELIAL DYSFUNCTION; SERUM ADIPONECTIN; HEART-DISEASE; SENSITIVITY; CYTOKINES; EXPRESSION; ASSOCIATION; METABOLISM;
D O I
10.1590/1806-9282.61.01.072
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: the conditions of obesity and overweight pose a major risk for a number of comorbidities, including clinical syndromes resulting from atherosclerotic disease. Recent studies strongly indicate that adipose tissue is an active endocrine organ that secretes bioactive factors such as adipokines. Adiponectin appears to have a regulatory role in the mechanism of insulin resistance and in the development of atherosclerosis. This systematic review aims to evaluate the anti-atherogenic effects of adiponectin and its properties to improve and mimic metabolic and vascular actions of insulin and its influence on endothelial function. Methods: a qualitative, exploratory and literature review was performed in the PubMed, Portal Capes and Scielo databases using as key-words "adiponectin", "obesity", "insulin resistance", "anti-inflammatory", "therapeutic strategies" and "future prospects". Results: evidence suggests that adiponectin has anti-atherogenic properties with anti-inflammatory effects on the vascular wall. Moreover, it modifies the vascular intracellular signaling and has indirect antioxidant effects on the human myocardium. On the other hand, there are studies suggesting that increased levels of adiponectin are paradoxically associated with a worse prognosis in heart failure syndrome, although the mechanisms are not clear. Conclusion: it is not clear whether adiponectin levels have any clinical significance for risk stratification in cardiovascular disease or if they simply reflect the activation of complex underlying mechanisms. Changes in lifestyle and some drug treatments for hypertension and coronary heart disease have shown significant effect to increase adiponectin levels, and simultaneously decrease in insulin resistance and endothelial dysfunction.
引用
收藏
页码:72 / 80
页数:9
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