Selective bindings of a lectin for phase-separated glycolipid monolayers

被引：16

作者：

Hashizume, M ^{[1
]}

Sato, T ^{[1
]}

Okahata, Y ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

CHEMISTRY LETTERS | 1998年 / 05期

关键词：

D O I：

10.1246/cl.1998.399

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phase separation was observed by measuring surface pressure (pi)-area (A) isotherms of the mixed monolayer of lactosylcerami de (LacCer) and dioleoylphosphatidylcholine (DOPC). Bindings of Allomyrina dichotoma (allo A) lectin to LacCer in mixed monolayers were measured by means of quartz-crystal microbalance (QCM) that was attached horizontally to the monolayers. Allo A showed the high binding affinity for the LacCer phase-separated in the DOPC monolayer, but showed the low binding affinity for the LacCer homogeneously mixed with dipalmitoylphosphatidylcholine (DPPC) matrix.

引用

页码：399 / 400

页数：2

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