A dendritic tetra(bisphosphonic acid) for improved targeting of proteins to bone

被引：40

作者：

Bansal, G

Wright, JEI

Kucharski, C

Uludag, H

机构：

[1] Univ Alberta, Dept Chem & Mat Engn, Edmonton, AB T6G 2G6, Canada

[2] Univ Alberta, Dept Biomed Engn, Fac Med, Edmonton, AB T6G 2G6, Canada

[3] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2G6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 24期

关键词：

D O I：

10.1002/anie.200500350

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Close to the bone: A dendritic molecule that contains four bone-seeking bisphosphonic acid groups (see picture) has been prepared for targeting proteins to bone tissue. The tetra(bisphosphonic acid) molecule provides a high density of bisphosphonic acid groups per attachment site at the protein and will aid the design of bone-seeking proteins with minimal modification. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3710 / 3714

页数：5

共 19 条

[1]

Alferiev IS, 2001, J POLYM SCI POL CHEM, V39, P105, DOI 10.1002/1099-0518(20010101)39:1<105::AID-POLA120>3.3.CO

[2]

2-#

[3]

Ames B. N., 1966, METHOD ENZYMOL, V8, P115, DOI DOI 10.1016/0076-6879(66)08014-5

[4]

BANSAL G, 2005, IN PRESS J BIOMED MA

[5] Quantitative studies of bone with the use of 18F-fluoride and 99mTc-methylene diphosphonate [J].

Blake, GM ;

Park-Holohan, SJ ;

Cook, GJR ;

Fogelman, I .

SEMINARS IN NUCLEAR MEDICINE, 2001, 31 (01) :28-49

[6]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[7] SYNTHESIS OF ETHENYLIDENEBIS(PHOSPHONIC ACID) AND ITS TETRAALKYL ESTERS [J].

DEGENHARDT, CR ;

BURDSALL, DC .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (18) :3488-3490

[8]

DELIGNY CL, 1990, NUCL MED BIOL, V17, P161

[9] Impact of tether length on bone mineral affinity of protein-bisphosphonate conjugates [J].

Gittens, SA ;

Kitov, PI ;

Matyas, JR ;

Löbenberg, R ;

Uludag, H .

PHARMACEUTICAL RESEARCH, 2004, 21 (04) :608-616

[10] Imparting bone affinity to glycoproteins through the conjugation of bisphosphonates [J].

Gittens, SA ;

Matyas, JR ;

Zernicke, RF ;

Uludag, H .

PHARMACEUTICAL RESEARCH, 2003, 20 (07) :978-987

← 1 2 →