Effect of rheumatoid arthritis or systemic lupus erythematosus on the risk of first-time acute myocardial infarction

被引：185

作者：

Fischer, LM

Schlienger, RG

Matter, C

Jick, H

Meier, CR

机构：

[1] Univ Basel Hosp, Div Clin Pharmacol & Toxicol, Basel Pharmacoepidemiol Unit, CH-4031 Basel, Switzerland

[2] Univ Zurich Hosp, Inst Physiol, CH-8091 Zurich, Switzerland

[3] Univ Zurich Hosp, Ctr Cardiovasc, Div Cardiol, CH-8091 Zurich, Switzerland

[4] Boston Univ, Med Ctr, Boston Collaborat Drug Surveillance Program, Lexington, MA USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2004年 / 93卷 / 02期

关键词：

D O I：

10.1016/j.amjcard.2003.09.037

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We explored the association between diagnosed rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and the risk of developing a first-time acute myocardial infarction (AMI) by conducting a population-based, case-control analysis using data from the United Kingdom-based General Practice Research Database (GPRD). Among 8,688. patients with AMI and 33,329 matched controls, the adjusted odds ratio (ORs) of AMI for subjects with RA was 1.47 (95% confidence interval [Cl]1.123 to 1.76), and in subjects with both RA and diagnosed hyperlipidemia, the OR was 7.12 (95% Cl 4.16 to 12.18). The risk associated with SLE was 2.67 (95% Cl 1.34 to 5.34). These results underline that RA and SLE increase the risk of AMI. (C) 2004 by Excerpta Medica, Inc.

引用

页码：198 / 200

页数：3

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