HIV-inhibitory natural products.: 50.: Vismiaphenones D-G, new prenylated benzophenones from Vismia cayennensis

被引:55
作者
Fuller, RW [1 ]
Westergaard, CK [1 ]
Collins, JW [1 ]
Cardellina, JH [1 ]
Boyd, MR [1 ]
机构
[1] NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Lab Drug Discovery Res & Dev,Dev Therapeut Progra, Frederick, MD 21702 USA
来源
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 01期
关键词
D O I
10.1021/np980152w
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Following anti-HIV bioassay-guided fractionation, four new prenylated benzophenones, vismiaphenones D-G (7-10), were isolated from extracts of leaves of Vismia cayennensis. The structures were elucidated by spectral analyses. Only vismiaphenone D (7) exhibited HIV-inhibitory activity in the NCI primary screen.
引用
收藏
页码:67 / 69
页数:3
相关论文
共 22 条
[1]   VISMIONE-H AND PRENYLATED XANTHONES FROM VISMIA-GUINEENSIS [J].
BOTTA, B ;
MONACHE, GD ;
MONACHE, FD ;
BETTOLO, GBM ;
MENICHINI, F .
PHYTOCHEMISTRY, 1986, 25 (05) :1217-1219
[2]   3-GERANYLOXY-6-METHYL-1,8-DIHYDROXYANTHRAQUINONE AND VISMIONE-C, VISMIONE-D AND VISMIONE-E FROM PSOROSPERMUM-FEBRIFUGUM [J].
BOTTA, B ;
DELLEMONACHE, F ;
DELLEMONACHE, G ;
BETTOLO, GBM ;
OGUAKWA, JU .
PHYTOCHEMISTRY, 1983, 22 (02) :539-542
[3]  
Boyd MR, 1997, CANC DRUG DISCOVERY, P23
[4]   CHEMISTRY OF THE VISMIA GENUS .8. 2-ISOPRENYLEMODIN AND 5,5'-DIMETHOXYSESAMIN FROM VISMIA GUARAMIRANGAE [J].
CAMELE, G ;
DELLEMONACHE, F ;
DELLEMONACHE, G ;
BETTOLO, GBM ;
DELIMA, RA .
PHYTOCHEMISTRY, 1982, 21 (02) :417-419
[5]  
Currens MJ, 1996, J PHARMACOL EXP THER, V279, P652
[6]  
Currens MJ, 1996, J PHARMACOL EXP THER, V279, P645
[7]  
DELLEMONACHE F, 1979, TETRAHEDRON, V35, P2143
[8]  
DELLEMONACHE F, 1983, PHYTOCHEMISTRY, V22, P227
[9]   CHEMISTRY OF THE VISMIA GENUS .6. PRENYLATED BENZOPHENONES FROM VISMIA-DECIPIENS [J].
DELLEMONACHE, G ;
GONZALEZ, JG ;
DELLEMONACHE, F ;
MARINIBETTOLO, GB .
PHYTOCHEMISTRY, 1980, 19 (09) :2025-2028
[10]   A BENZOPHENONE FROM THE FRUITS OF CLUSIA-ELLIPTICIFOLIA [J].
GONZALEZ, JG ;
CUELLAR, V ;
BETANCOURT, A ;
PINZON, MI .
PHYTOCHEMISTRY, 1983, 22 (09) :2088-2090