The role of hepatocyte growth factor and its receptor c-Met in multiple myeloma and other blood malignancies

被引:36
作者
Borset, M [1 ]
Seidel, C [1 ]
Hjorth-Hansen, H [1 ]
Waage, A [1 ]
Sundan, A [1 ]
机构
[1] Norwegian Univ Sci & Technol Hosp, Medisinsk Teknisk Senter, Inst Canc Res & Mol Biol, N-7005 Trondheim, Norway
关键词
hepatocyte growth factor; receptor c-Met; multiple myeloma; blood malignancies;
D O I
10.3109/10428199909167385
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The cytokine hepatocyte growth factor (HGF) and its receptor c-Met are a ligand-receptor pair with important functions in a communicative interplay between HGF-producing, mesenchymal cells and c-Met-expressing, target cells. HGF is cytoprotective and causes regeneration of parenchyma after tissue damage in several organs. The receptor c-Met was first characterized as an oncogene product being responsible for the transformation of an osteosarcoma cell line. KGF or c-Met is overexpressed in several human cancers, including various carcinomas. Some cells of hematopoietic origin also seem to be capable of c-Met expression, but the precise role of HGF in normal hematopoiesis is yet to be determined. In blood malignancies like acute myelogenous leukemia and, notably, multiple myeloma, HGF is overproduced and has implications for the prognosis of the patients. Biological significance of HGF overexpression in multiple myeloma is discussed and is likely to include effects on bone turnover and angiogenesis.
引用
收藏
页码:249 / 256
页数:8
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