New Cytotoxic Cucurbitacins from Wilbrandia ebracteata Cogn.

被引：13

作者：

Lang, Karen L. ^{[2
]}

Da Rosa Guimaraes, Tatiana ^{[1
]}

Rocha Machado, Vanessa ^{[1
]}

Zimmermann, Lara A. ^{[1
]}

Silva, Izabella T. ^{[1
]}

Teixeira, Marina R. ^{[1
]}

Duran, Fernando J. ^{[3
]}

Palermo, Jorge A. ^{[3
]}

Simoes, Claudia M. O. ^{[1
]}

Caro, Miguel S. B.

Schenkel, Eloir P. ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Ctr Hlth Sci, Dept Pharmaceut Sci, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Chem, BR-88040900 Florianopolis, SC, Brazil

[3] Univ Buenos Aires, Dept Organ Chem, UMYMFOR, Buenos Aires, DF, Argentina

来源：

PLANTA MEDICA | 2011年 / 77卷 / 14期

关键词：

Wilbrandia ebracteata; Cucurbitaceae; cucurbitacins; cytotoxicity;

D O I：

10.1055/s-0030-1270962

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (1-2) and four known (3-6) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity.

引用

页码：1648 / U100

页数：4

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