Cellular strategies for proteolytic targeting during migration and invasion

被引：43

作者：

Ellis, V ^{[1
]}

Murphy, G ^{[1
]}

机构：

[1] Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England

来源：

FEBS LETTERS | 2001年 / 506卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

serine proteinase; metalloproteinase; cell membrane; extracellular matrix; migration;

D O I：

10.1016/S0014-5793(01)02845-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell migration over or through the extracellular matrix (ECM) is an integral feature of both physiological and pathological processes. Regulation of the changing cell-ECM interactions involved can be effected by proteolysis and requires strict spatial and temporal targeting of proteinase activity. The versatile use of different proteinase systems, with a variety of localisation mechanisms and cleavage targets, is being revealed by a plethora of studies using in vitro models. This mini review reflects the status of our knowledge of strategies for the localisation of proteolytic activity effected during cell migration.(C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science BN. All rights reserved.

引用

页码：1 / 5

页数：5

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