Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism

被引：136

作者：

Tanaka, K ^{[1
]}

Hao, ZL ^{[1
]}

Kai, M ^{[1
]}

Okayama, H ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Biochem & Mol Biol, Bunkyo Ku, Tokyo 1130033, Japan

来源：

EMBO JOURNAL | 2001年 / 20卷 / 20期

关键词：

cohesin; Eso1p; fission yeast; Pds5p; sister chromatid cohesion;

D O I：

10.1093/emboj/20.20.5779

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin-associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p-homologous domain.

引用

页码：5779 / 5790

页数：12

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