HDAC inhibitors in HIV

被引：107

作者：

Wightman, Fiona ^{[2
,3
]}

Ellenberg, Paula ^{[2
,3
]}

Churchill, Melissa ^{[3
]}

Lewin, Sharon R. ^{[1
,2
,3
]}

机构：

[1] Alfred Hosp, Infect Dis Unit, Melbourne, Vic 3004, Australia

[2] Monash Univ, Dept Med, Melbourne, Vic 3004, Australia

[3] Burnet Inst, Ctr Virol, Melbourne, Vic, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2012年 / 90卷 / 01期

关键词：

cure; HDAC inhibitor; HIV; latency; transcription; HUMAN-IMMUNODEFICIENCY-VIRUS; HISTONE DEACETYLASE INHIBITOR; CD4(+) T-CELLS; NF-KAPPA-B; COMBINATION ANTIRETROVIRAL THERAPY; REACTIVATES LATENT HIV-1; TUMOR-NECROSIS-FACTOR; LONG TERMINAL REPEAT; HUMAN-FACTORS YY1; VALPROIC ACID;

D O I：

10.1038/icb.2011.95

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Combination antiretroviral therapy (cART) has led to a very substantial reduction in morbidity and mortality in HIV-infected patients; however, cART alone is unable to cure HIV and therapy is lifelong. Therefore, a new strategy to cure HIV is urgently needed. There is now a concerted effort from scientists, clinicians and funding agencies to identify ways to achieve either a functional cure (long-term control of HIV in the absence of cART) or a sterilizing cure (elimination of all HIV-infected cells). Multiple strategies aiming at achieving a cure for HIV are currently being investigated, including both pharmacotherapy and gene therapy. In this review, we will review the rationale as well as in vitro and clinical trial data that support the role of histone deacetylase inhibitors as one approach to cure HIV. Immunology and Cell Biology (2012) 90, 47-54; doi: 10.1038/icb.2011.95; published online 15 November 2011

引用

收藏

页码：47 / 54

页数：8

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