The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma

被引：50

作者：

Frank, AJ

Hernan, R

Hollander, A

Lindsey, JC

Lusher, ME

Fuller, CE

Clifford, SC

Gilbertson, RJ

机构：

[1] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[3] Univ Newcastle, Sch Med, No Inst Canc Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

MOLECULAR BRAIN RESEARCH | 2004年 / 121卷 / 1-2期

关键词：

medulloblastoma; anaplastic; TP53; ARF; INK4A;

D O I：

10.1016/j.molbrainres.2003.11.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We analyzed the TP53 and INK4A/ARF loci in 29 pediatric medulloblastomas. Mutually exclusive mutation in TP53, methylation of P14(ARF) or deletion of INK4A/ARF were identified in 21% (6/29) of tumors. Five of these alterations were detected in large cell/anaplastic medulloblastomas or tumors with significant anaplasia. Our data provide the first evidence that alterations within the TP53-ARF tumor suppressor pathway contribute to development of aggressive forms of medulloblastoma. (C) 2004 Elsevier B.V. All rights reserved.

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收藏

页码：137 / 140

页数：4

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