Trisomies in multiple myeloma: impact on survival in patients with high-risk cytogenetics

被引：205

作者：

Kumar, Shaji ^{[1
]}

Fonseca, Rafael ^{[2
]}

Ketterling, Rhett P. ^{[3
]}

Dispenzieri, Angela ^{[1
]}

Lacy, Martha Q. ^{[1
]}

Gertz, Morie A. ^{[1
]}

Hayman, Suzanne R. ^{[1
]}

Buadi, Francis K. ^{[1
]}

Dingli, David ^{[1
]}

Knudson, Ryan A. ^{[3
]}

Greenberg, Alexandra

Russell, Stephen J. ^{[1
]}

Zeldenrust, Steven R. ^{[1
]}

Lust, John A. ^{[1
]}

Kyle, Robert A. ^{[1
]}

Bergsagel, Leif ^{[2
]}

Rajkumar, S. Vincent ^{[1
]}

机构：

[1] Mayo Clin, Div Hematol, Dept Internal Med, Rochester, MN 55906 USA

[2] Mayo Clin, Div Hematol & Oncol, Scottsdale, AZ USA

[3] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55906 USA

来源：

BLOOD | 2012年 / 119卷 / 09期

基金：

美国国家卫生研究院;

关键词：

IN-SITU HYBRIDIZATION; HIGH-DOSE THERAPY; STEM-CELL TRANSPLANTATION; P53 GENE DELETION; PROGNOSTIC-FACTOR; HYPERDIPLOID-MYELOMA; FISH ANALYSIS; STRATIFICATION; ABNORMALITIES; DEXAMETHASONE;

D O I：

10.1182/blood-2011-11-390658

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Routine incorporation of FISH into multiple myeloma (MM) diagnostic testing has led to a better appreciation of the heterogeneity of genetic abnormalities associated with this disease. We studied a group of 484 patients with newly diagnosed symptomatic MM to better understand the prevalence of the various abnormalities and the prognostic significance of the overlapping abnormalities. A translocation involving the IgH locus and 1 of the 5 recurrent partner chromosomes was seen in 161 (33%) patients, and 275 (57%) had trisomy of at least 1 odd-numbered chromosome. High-risk FISH, defined as the presence of t(4;14), t(14;16), t(14;20), or loss of P53, was seen in 115 (24%) patients; the median overall survival for this group was 3.9 years, compared with "not reached" for standard-risk patients (P < .001). Among the patients with high-risk FISH, 49 patients who also had at least 1 trisomy had a median overall survival that was not reached, compared with 3 years for high-risk patients without a concurrent trisomy (P = .01). Based on the current findings, we conclude that the presence of trisomies in patients with t(4;14), t(14;16), t(14;20), or p53 deletion abnormalities in MM ameliorates the usual adverse impact associated with these prognostic markers. (Blood. 2012; 119(9): 2100-2105)

引用

页码：2100 / 2105

页数：6

共 28 条

[1]

Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myelome [J].

Avet-Loiseau, Herve ;

Attal, Michel ;

Moreau, Philippe ;

Charbonnel, Catherine ;

Garban, Frederic ;

Hulin, Cyrille ;

Leyvraz, Serge ;

Michallet, Mauricette ;

Yakoub-Agha, Ibrahim ;

Garderet, Laurent ;

Marit, Gerald ;

Michaux, Lucienne ;

Voillat, Laurent ;

Renaud, Marc ;

Grosbois, Bernard ;

Guillerm, Gaelle ;

Benboubker, Lotfi ;

Monconduit, Mathieu ;

Thieblemont, Catherine ;

Casassus, Philippe ;

Caillot, Denis ;

Stoppa, Anne-Marie ;

Sotto, Jean-Jacques ;

Wetterwald, Marc ;

Dumontet, Charles ;

Fuzibet, Jean-Gabriel ;

Azais, Isabelle ;

Dorvaux, Veronique ;

Zandecki, Marc ;

Bataille, Regis ;

Minvielle, Stephane ;

Harousseau, Jean-Luc ;

Facon, Thierry ;

Mathiot, Claire .

BLOOD, 2007, 109 (08) :3489-3495

[2]

Bortezomib Plus Dexamethasone Induction Improves Outcome of Patients With t(4;14) Myeloma but Not Outcome of Patients With del(17p) [J].

Avet-Loiseau, Herve ;

Leleu, Xavier ;

Roussel, Murielle ;

Moreau, Philippe ;

Guerin-Charbonnel, Catherine ;

Caillot, Denis ;

Marit, Gerald ;

Benboubker, Lotfi ;

Voillat, Laurent ;

Mathiot, Claire ;

Kolb, Brigitte ;

Macro, Margaret ;

Campion, Loic ;

Wetterwald, Marc ;

Stoppa, Anne-Marie ;

Hulin, Cyrille ;

Facon, Thierry ;

Attal, Michel ;

Minvielle, Stephane ;

Harousseau, Jean-Luc .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (30) :4630-4634

[3]

p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation [J].

Chang, H ;

Qi, C ;

Yi, QL ;

Reece, D ;

Stewart, AK .

BLOOD, 2005, 105 (01) :358-360

[4]

Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma [J].

Chiecchio, L. ;

Protheroe, R. K. M. ;

Ibrahim, A. H. ;

Cheung, K. L. ;

Rudduck, C. ;

Dagrada, G. P. ;

Cabanas, E. D. ;

Parker, T. ;

Nightingale, M. ;

Wechalekar, A. ;

Orchard, K. H. ;

Harrison, C. J. ;

Cross, N. C. P. ;

Morgan, G. J. ;

Ross, F. M. .

LEUKEMIA, 2006, 20 (09) :1610-1617

[5]

Prognostic factors for hyperdiploid-myeloma:: effects of chromosome 13 deletions and IgH translocations [J].

Chng, W ;

Santana-Dávila, R ;

Van Wier, S ;

Ahmann, GJ ;

Jalal, SM ;

Bergsagel, PL ;

Chesi, M ;

Trendle, MC ;

Jacobus, S ;

Blood, E ;

Oken, MM ;

Henderson, K ;

Kyle, RA ;

Gertz, MA ;

Lacy, MQ ;

Dispenzieri, A ;

Greipp, PR ;

Fonseca, R .

LEUKEMIA, 2006, 20 (05) :807-813

[6]

Do β2 microglobulin levels affect survival of newly diagnosed myeloma patients with translocation t(4;14) or 17p13 deletion treated with conventional chemotherapy? [J].

Chng, W. J. ;

Jacobus, S. ;

Fonseca, R. .

LEUKEMIA, 2008, 22 (05) :1080-1081

[7]

Molecular dissection of hyperdiploid multiple myeloma by gene expression profiling [J].

Chng, Wee J. ;

Kumar, Shaji ;

VanWier, Scott ;

Ahmann, Greg ;

Price-Troska, Tammy ;

Henderson, Kim ;

Chung, Tae-Hoon ;

Kim, Seungchan ;

Mulligan, George ;

Bryant, Barbara ;

Carpten, John ;

Gertz, Morie ;

Rajkumar, S. Vincent ;

Lacy, Martha ;

Dispenzieri, Angela ;

Kyle, Robert ;

Greipp, Philip ;

Bergsagel, P. Leif ;

Fonseca, Rafael .

CANCER RESEARCH, 2007, 67 (07) :2982-2989

[8]

Analysis of genetic abnormalities provides insights into genetic evolution of hyperdiploid myeloma [J].

Chng, Wee J. ;

Ketterling, Rhett P. ;

Fonseca, Rafael .

GENES CHROMOSOMES & CANCER, 2006, 45 (12) :1111-1120

[9]

A validated FISH trisony index demonstrates the hyperdiploid and nonhyperdiploid dichotomy in MGUS [J].

Chng, WJ ;

Van Wier, SA ;