Unveiling the Secrets of the Ancestral PI3 Kinase Vps34

被引：13

作者：

Workman, Paul ^{[1
,2
]}

van Montfort, Rob L. M. ^{[1
,2
,3
]}

机构：

[1] Inst Canc Res, Canc Res UK Ctr Canc Therapeut, Haddow Labs, Sutton SM2 5NG, Surrey, England

[2] Inst Canc Res, Sect Canc Therapeut, Haddow Labs, Sutton SM2 5NG, Surrey, England

[3] Inst Canc Res, Chester Beatty Labs, Sect Struct Biol, London SW3 6JB, England

来源：

CANCER CELL | 2010年 / 17卷 / 05期

关键词：

AUTOPHAGY; MECHANISMS;

D O I：

10.1016/j.ccr.2010.04.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：421 / 423

页数：3

共 11 条

[1] The regulation and function of Class III PI3Ks: novel roles for Vps34 [J].

Backer, Jonathan M. .

BIOCHEMICAL JOURNAL, 2008, 410 (01) :1-17

[2]

Berndt A, 2010, NAT CHEM BIOL, V6, P117, DOI [10.1038/nchembio.293, 10.1038/NCHEMBIO.293]

[3] The Beclin 1-VPS34 complex - at the crossroads of autophagy and beyond [J].

Funderburk, Sarah F. ;

Wang, Qing Jun ;

Yue, Zhenyu .

TRENDS IN CELL BIOLOGY, 2010, 20 (06) :355-362

[4] The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations [J].

Huang, Chuan-Hsiang ;

Mandelker, Diana ;

Schmidt-Kittler, Oleg ;

Samuels, Yardena ;

Velculescu, Victor E. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Gabelli, Sandra B. ;

Amzel, L. Mario .

SCIENCE, 2007, 318 (5857) :1744-1748

[5] The role of autophagy in cancer development and response to therapy [J].

Kondo, Y ;

Kanzawa, T ;

Sawaya, R ;

Kondo, S .

NATURE REVIEWS CANCER, 2005, 5 (09) :726-734

[6] Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34 [J].

Miller, Simon ;

Tavshanjian, Brandon ;

Oleksy, Arkadiusz ;

Perisic, Olga ;

Houseman, Benjamin T. ;

Shokat, Kevan M. ;

Williams, Roger L. .

SCIENCE, 2010, 327 (5973) :1638-1642

[7] Signaling From the Golgi: Mechanisms and Models for Golgi Phosphoprotein 3-Mediated Oncogenesis [J].

Scott, Kenneth L. ;

Chin, Lynda .

CLINICAL CANCER RESEARCH, 2010, 16 (08) :2229-2234

[8] Synthesis and function of 3-phosphorylated inositol lipids [J].

Vanhaesebroeck, B ;

Leevers, SJ ;

Ahmadi, K ;

Timms, J ;

Katso, R ;

Driscoll, PC ;

Woscholski, R ;

Parker, PJ ;

Waterfield, MD .

ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 :535-602

[9] Structural insights into phosphoinositide 3-kinase catalysis and signalling [J].

Walker, EH ;

Perisic, O ;

Ried, C ;

Stephens, L ;

Williams, RL .

NATURE, 1999, 402 (6759) :313-320

[10] The Double-Edged Sword of Autophagy Modulation in Cancer [J].

White, Eileen ;

DiPaola, Robert S. .

CLINICAL CANCER RESEARCH, 2009, 15 (17) :5308-5316

← 1 2 →