Tryptase concentrations in bronchoalveolar lavage from patients with chronic eosinophilic pneumonia

被引：14

作者：

Bargagli, E ^{[1
]}

Bigliazzi, C ^{[1
]}

Leonini, A ^{[1
]}

Nikiforakis, N ^{[1
]}

Perari, MG ^{[1
]}

Rottoli, P ^{[1
]}

机构：

[1] Univ Siena, Le Scotte Hosp, Resp Dis Sect, Dept Clin Med & Immunol Sci, I-53100 Siena, Italy

来源：

CLINICAL SCIENCE | 2005年 / 108卷 / 03期

关键词：

bronchoalverolar lavage; chronic eosinophilic pneumonia; eosinophil; mast cell; tryptase;

D O I：

10.1042/CS20040178

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In order to characterize BAL (bronchoalveolar lavage) in CEP (chronic eosinophilic pneumonia) and to investigate the possible role of mast cells and tryptase in the pathogenesis of this interstitial disease, cells and tryptase levels were determined in BAL of patients with CEP and in a group of healthy controls. The results show that a statistically significant increase in tryptase concentration was found in patients with CEP compared with the healthy controls. This is the first report that shows an increase in tryptase levels in CEP and could reflect higher mast cell activation as well as larger mast cell populations in the lungs of these patients. These results strongly support the involvement of mast cells and eosinophils in the immunopathogenesis of CEP.

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页码：273 / 276

页数：4

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