The Santa Lucia strain of Plasmodium falciparum as a model for vaccine studies .1. Development in Aotus lemurinus griseimembra monkeys

被引：16

作者：

Collins, WE ^{[1
]}

Galland, GG ^{[1
]}

Sullivan, JS ^{[1
]}

Morris, CL ^{[1
]}

Richardson, BB ^{[1
]}

Roberts, JM ^{[1
]}

机构：

[1] CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,SCI RESOURCES PROGRAM,ATLANTA,GA 30333

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1996年 / 54卷 / 04期

关键词：

D O I：

10.4269/ajtmh.1996.54.372

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The Santa Lucia strain of Plasmodium falciparum and the Aotus lemurinus griseimembra monkey are proposed as models for the testing of sporozoite vaccines and transmission-blocking vaccines. Approximately 85% of splenectomized monkeys were infected when fed upon by 10 or more heavily infected Anopheles freeborni mosquitoes. Sporozoite-induced infections in monkeys with or without previous infection with P. vivax readily infected mosquitoes, thus making them candidates for testing transmission-blocking vaccines.

引用

页码：372 / 379

页数：8

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