AACR Project GENIE: Powering Precision Medicine through an International Consortium

被引：1437

作者：

Andre, Fabrice ^{[1
]}

Arnedos, Monica ^{[1
]}

Baras, Alexander S. ^{[2
]}

Baselga, Jose ^{[3
]}

Bedard, Philippe L. ^{[4
]}

Berger, Michael F. ^{[3
]}

Bierkens, Mariska ^{[5
]}

Calvo, Fabien ^{[1
]}

Cerami, Ethan ^{[6
]}

Chakravarty, Debyani ^{[3
]}

Dang, Kristen K. ^{[7
]}

Davidson, Nancy E. ^{[8
]}

Del Vecchio, Fitz Catherine ^{[6
]}

Dogan, Semih ^{[1
]}

DuBois, Raymond N. ^{[9
]}

Ducar, Matthew D. ^{[6
,10
]}

Futreal, P. Andrew ^{[11
]}

Gao Jianjiong ^{[3
]}

Garcia, Francisco ^{[11
]}

Gardos, Stu ^{[3
]}

Gocke, Christopher D. ^{[2
]}

Gross, Benjamin E. ^{[3
]}

Guinney, Justin ^{[7
]}

Heins, Zachary J. ^{[3
]}

Hintzen, Stephanie ^{[6
]}

Horlings, Hugo ^{[5
]}

Hudecek, Jan ^{[5
]}

Hyman, David M. ^{[3
]}

Kamel-Reid, Suzanne ^{[4
]}

Kandoth, Cyriac ^{[3
]}

Kinyua, Walter ^{[11
]}

Kumari, Priti ^{[6
]}

Kundra, Ritika ^{[3
]}

Ladanyi, Marc ^{[3
]}

Lefebvre, Celine ^{[1
]}

LeNoue-Newton, Michele L. ^{[12
]}

Lepisto, Eva M. ^{[6
]}

Levy, Mia A. ^{[12
]}

Lindeman, Neal, I ^{[13
,14
]}

Lindsay, James ^{[6
]}

Liu, David ^{[6
]}

Lu Zhibin ^{[4
]}

MacConaill, Laura E. ^{[13
,14
]}

Ian, Maurer ^{[15
]}

Maxwell, David S. ^{[11
]}

Meijer, Gerrit A. ^{[5
]}

Meric-Bernstam, Funda ^{[11
]}

Micheel, Christine M. ^{[12
]}

Miller, Clinton ^{[15
]}

Mills, Gordon ^{[11
]}

机构：

[1] Inst Gustave Roussy, Villejuif, France

[2] Johns Hopkins Univ, Sidney Kimmel Canc Ctr, Baltimore, MD 21218 USA

[3] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA

[4] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada

[5] Netherlands Canc Inst, Amsterdam, Netherlands

[6] Dana Farber Canc Inst, 450 Brookline Ave, Boston, MA 02215 USA

[7] Sage Bionetworks, Seattle, WA USA

[8] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[9] Med Univ South Carolina, Charleston, SC USA

[10] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[11] UT MD Anderson Canc Ctr, Houston, TX USA

[12] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[13] Brigham & Womens Hosp, Dana Farber Canc Inst, 75 Francis St, Boston, MA 02115 USA

[14] Harvard Med Sch, Boston, MA USA

[15] GenomOncology, Cleveland, OH USA

[16] Howard Hughes Med Inst Investigator, San Diego, CA USA

[17] Amer Assoc Canc Res, Philadelphia, PA USA

[18] UCSF Helen Diller Family Comp, Ctr Canc, San Francisco, CA USA

来源：

CANCER DISCOVERY | 2017年 / 7卷 / 08期

关键词：

CANCER; ONCOLOGY;

D O I：

10.1158/2159-8290.CD-17-0151

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The AACR Project GENIE is an international data-sharing consortium focused on generating an evidence base for precision cancer medicine by integrating clinicalgrade cancer genomic data with clinical outcome data for tens of thousands of cancer patients treated at multiple institutions worldwide. In conjunction with the first public data release from approximately 19,000 samples, we describe the goals, structure, and data standards of the consortium and report conclusions from high-level analysis of the initial phase of genomic data. We also provide examples of the clinical utility of GENIE data, such as an estimate of clinical actionability across multiple cancer types (> 30%) and prediction of accrual rates to the NCI-MATCH trial that accurately reflect recently reported actual match rates. The GENIE database is expected to grow to > 100,000 samples within 5 years and should serve as a powerful tool for precision cancer medicine. SIGNIFICANCE: The AACR Project GENIE aims to catalyze sharing of integrated genomic and clinical datasets across multiple institutions worldwide, and thereby enable precision cancer medicine research, including the identification of novel therapeutic targets, design of biomarker-driven clinical trials, and identification of genomic determinants of response to therapy.

引用

页码：818 / 831

页数：14

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