Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia
被引:91
作者:
Kainulainen, Leena
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机构:
Turku Univ Hosp, Dept Pediat, Turku 20521, Finland
Turku Univ Hosp, Dept Internal Med, Turku 20521, FinlandTurku Univ Hosp, Dept Pediat, Turku 20521, Finland
Kainulainen, Leena
[1
,2
]
Vuorinen, Tytti
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机构:
Turku Univ, Dept Virol, Turku, FinlandTurku Univ Hosp, Dept Pediat, Turku 20521, Finland
Vuorinen, Tytti
[4
]
Rantakokko-Jalava, Kaisu
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机构:
Turku Univ Hosp, Dept Med Microbiol, Turku 20521, FinlandTurku Univ Hosp, Dept Pediat, Turku 20521, Finland
Rantakokko-Jalava, Kaisu
[3
]
Osterback, Riikka
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机构:
Turku Univ, Dept Virol, Turku, FinlandTurku Univ Hosp, Dept Pediat, Turku 20521, Finland
Osterback, Riikka
[4
]
Ruuskanen, Olli
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Turku Univ Hosp, Dept Pediat, Turku 20521, FinlandTurku Univ Hosp, Dept Pediat, Turku 20521, Finland
Ruuskanen, Olli
[1
]
机构:
[1] Turku Univ Hosp, Dept Pediat, Turku 20521, Finland
[2] Turku Univ Hosp, Dept Internal Med, Turku 20521, Finland
[3] Turku Univ Hosp, Dept Med Microbiol, Turku 20521, Finland
Background: The occurrence of respiratory tract viral infections in patients with primary hypogammaglobulinemia has not been studied. Objective: We conducted a prospective 12-month follow-up study of respiratory tract infections in 12 adult patients with primary hypogammaglobulinemia. Methods: Nasal swab samples and induced sputum samples were taken at the onset of acute respiratory tract infection and every 3 months thereafter. Samples were tested for bacteria and viruses. PCR tests were performed for 15 respiratory tract viruses. In case the results for rhinovirus were positive, follow-up nasal swab samples were taken every 2 weeks until rhinoviral PCR results became negative. Patients completed symptom diaries, which were collected every month. The spouses of the patients served as healthy control subjects. Results: During the 12-month period, the 12 patients had 65 episodes of acute respiratory tract infections, and the 11 spouses had 12 acute episodes (P<.001). Respiratory tract viruses were found in sputum in 54% of the infections. Rhinovirus was the most common virus. In more than half of our patients, rhinoviral PCR results stayed positive for more than 2 months. The most long-acting persistence with the same rhinovirus was 4 months. Conclusions: Despite adequate immunoglobulin replacement therapy, patients with primary hypogammaglobulinemia have increased susceptibility to respiratory tract viral infections. Rhinoviral infections are frequent and prolonged. (J Allergy Clin Immunol 2010;126:120-6.)
机构:
Mt Sinai Med Ctr, Dept Med & Pediat, Div Clin Immunol, New York, NY 10029 USAMt Sinai Med Ctr, Dept Med & Pediat, Div Clin Immunol, New York, NY 10029 USA
Cunningham-Rundles, C
;
Bodian, C
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机构:Mt Sinai Med Ctr, Dept Med & Pediat, Div Clin Immunol, New York, NY 10029 USA
机构:
Mt Sinai Med Ctr, Dept Med & Pediat, Div Clin Immunol, New York, NY 10029 USAMt Sinai Med Ctr, Dept Med & Pediat, Div Clin Immunol, New York, NY 10029 USA
Cunningham-Rundles, C
;
Bodian, C
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机构:Mt Sinai Med Ctr, Dept Med & Pediat, Div Clin Immunol, New York, NY 10029 USA