Effects of prefrontal cortical lesions on neuropeptide and dopamine receptor gene expression in the striatum-accumbens complex

被引:13
作者
Baca, SM [1 ]
Lipska, BK [1 ]
Egan, MF [1 ]
Bachus, SE [1 ]
Ferguson, JN [1 ]
Hyde, TM [1 ]
机构
[1] NIMH, St Elizabeths Hosp, Clin Brain Disorders Branch, Intramural Res Program,Neurosci Ctr, Washington, DC 20032 USA
关键词
mPFC lesions; in situ hybridization histochemistry; basal ganglia; D2; D1; enkephalin; GAD65; substance P;
D O I
10.1016/S0006-8993(98)00343-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the rat, neurochemical, behavioral, and anatomical investigations suggest that medial prefrontal cortical input modulates the activity of the basal ganglia. To understand how prefrontal dysfunction might alter striatal-accumbens function, in situ hybridization histochemistry with S-35-labeled oligonucleotide probes was used to assess changes in striaral-accumbens gene expression following bilateral excitotoxic ibotenic acid (IA) lesions of the rat medial prefrontal cortex. Quantitative densitometry was used to measure changes in mRNA levels for preproenkephalin A (ENK), D1 dopamine receptor, protachykinin (SubP), glutamic acid decarboxylase (GAD65), and D2 dopamine receptor. No differences were found between sham and lesion groups for ENK, D1, SubP, or GAD65 mRNA levels in the striatum or nucleus accumbens (NAC). D2 receptor mRNA levels were, however, significantly higher in the dorsomedial striatum and in the core area of the NAC of the lesioned rats. Although the functional significance of increased D2 mRNA is unclear, these findings demonstrate that glutamate mPFC projections modulate gene expression in relatively regionally-localized subcortical neuronal populations. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:55 / 64
页数:10
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