Immunologic Basis of Vaccine Vectors

被引：194

作者：

Liu, Margaret A. ^{[1
,2
]}

机构：

[1] ProTherImmune, Lafayette, CA 94549 USA

[2] Karolinska Inst, Dept Microbiol & Tumor Cell Biol, SE-17177 Stockholm, Sweden

来源：

IMMUNITY | 2010年 / 33卷 / 04期

关键词：

CYTOTOXIC T-LYMPHOCYTES; GENE-BASED VACCINES; DEFECTIVE ADENOVIRUS VECTORS; HEMATOPOIETIC NECROSIS VIRUS; ANTIGEN-PRESENTING CELLS; HIGHLY CONSERVED REGION; DNA VACCINE; HIV-1; VACCINE; IMMUNE-RESPONSES; MESSENGER-RNA;

D O I：

10.1016/j.immuni.2010.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Efforts to make vaccines against infectious diseases as well as immunotherapies for cancer, autoimmune diseases and allergy have utilized a variety of heterologous expression systems, including viral and bacterial vectors, as well as DNA and RNA constructs This review explores the immunologic rationale and provides an update of insights obtained from preclinical and clinical studies of such vaccines

引用

页码：504 / 515

页数：12

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