Where are the prostate cancer genes? A summary of eight genome wide searches

被引：79

作者：

Easton, DF

Schaid, DJ

Whittemore, AS

Isaacs, WJ

机构：

[1] Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Canc Res UK,Genet Epidemiol Unit, Cambridge CB1 8RN, England

[2] Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Rochester, MN 55905 USA

[3] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA

[4] Johns Hopkins Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD 21205 USA

来源：

PROSTATE | 2003年 / 57卷 / 04期

关键词：

genetic linkage analysis; ICPCG; prostate cancer susceptibility; parametric linkage; non-parametric linkage;

D O I：

10.1002/pros.10300

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND. There is strong evidence for genetic susceptibility to prostate cancer, but most of the genes underlying this susceptibility remain to be identified. METHODS. We reviewed the results of eight genome-wide linkage searches based on 1,293 families with multiple cases of prostate cancer. RESULTS. Across these studies, 11 linkage peaks with LOD scores in excess of 2 were identified. However, no chromosomal region was reported as significant at this level by more than one study and only one corresponded to a peak previously suggested by another group. CONCLUSIONS. These results indicate that prostate cancer is genetically complex, and that combined analyses of large family sets will be required to evaluate reliably the linkage evidence.

引用

页码：261 / 269

页数：9

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