Lipoprotein receptors: beacons to neurons?

被引：15

作者：

Herz, J ^{[1
]}

机构：

[1] Univ Texas SW, Dept Mol Genet, Dallas, TX 75390 USA

来源：

TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 04期

关键词：

D O I：

10.1016/S0166-2236(00)01768-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lipoprotein receptors were originally considered simply as cellular transporters for cholesterol and other lipids. This view is rapidly changing. Signaling functions have recently been recognized in several members of the low-density lipoprotein receptor gene family. These Apolipoprotein E receptors are highly expressed in the developing and in the mature nervous system, in which they regulate crucial developmental processes and might also participate in synaptic neurotransmission.

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收藏

页码：193 / 195

页数：3

相关论文

共 12 条

[1] The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors [J].

Bacskai, BJ ;

Xia, MQ ;

Strickland, DK ;

Rebeck, GW ;

Hyman, BT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) :11551-11556

[2] APOLIPOPROTEIN-E ASSOCIATED WITH ASTROCYTIC GLIA OF THE CENTRAL NERVOUS-SYSTEM AND WITH NONMYELINATING GLIA OF THE PERIPHERAL NERVOUS-SYSTEM [J].

BOYLES, JK ;

PITAS, RE ;

WILSON, E ;

MAHLEY, RW ;

TAYLOR, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (04) :1501-1513

[3] A ROLE FOR APOLIPOPROTEIN-E, APOLIPOPROTEIN-A-I, AND LOW-DENSITY LIPOPROTEIN RECEPTORS IN CHOLESTEROL TRANSPORT DURING REGENERATION AND REMYELINATION OF THE RAT SCIATIC-NERVE [J].

BOYLES, JK ;

ZOELLNER, CD ;

ANDERSON, LJ ;

KOSIK, LM ;

PITAS, RE ;

WEISGRABER, KH ;

HUI, DY ;

MAHLEY, RW ;

GEBICKEHAERTER, PJ ;

IGNATIUS, MJ ;

SHOOTER, EM .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (03) :1015-1031

[4] Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction [J].

Gotthardt, M ;

Trommsdorff, M ;

Nevitt, MF ;

Shelton, J ;

Richardson, JA ;

Stockinger, W ;

Nimpf, J ;

Herz, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (33) :25616-25624

[5] Apolipoprotein E receptors: Linking brain development and Alzheimer's disease [J].

Herz, J ;

Beffert, U .

NATURE REVIEWS NEUROSCIENCE, 2000, 1 (01) :51-58

[6] An LDL-receptor-related protein mediates Wnt signalling in mice [J].

Pinson, KI ;

Brennan, J ;

Monkley, S ;

Avery, BJ ;

Skarnes, WC .

NATURE, 2000, 407 (6803) :535-538

[7] INCREASED AMYLOID BETA-PEPTIDE DEPOSITION IN CEREBRAL-CORTEX AS A CONSEQUENCE OF APOLIPOPROTEIN-E GENOTYPE IN LATE-ONSET ALZHEIMER-DISEASE [J].

SCHMECHEL, DE ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

CRAIN, BJ ;

HULETTE, CM ;

JOO, SH ;

PERICAKVANCE, MA ;

GOLDGABER, D ;

ROSES, AD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (20) :9649-9653

[8] Molecular genetics of Alzheimer Disease [J].

St George-Hyslop, PH .

SEMINARS IN NEUROLOGY, 1999, 19 (04) :371-383

[9] LDL-receptor-related proteins in Wnt signal transduction [J].

Tamai, K ;

Semenov, M ;

Kato, Y ;

Spokony, R ;

Liu, CM ;

Katsuyama, Y ;

Hess, F ;

Saint-Jeannet, JP ;

He, X .

NATURE, 2000, 407 (6803) :530-535

[10] Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2 [J].

Trommsdorff, M ;

Gotthardt, M ;

Hiesberger, T ;

Shelton, J ;

Stockinger, W ;

Nimpf, J ;

Hammer, RE ;

Richardson, JA ;

Herz, J .

CELL, 1999, 97 (06) :689-701