Molecular mimicry reflected through database screening: Serendipity or survival strategy?

被引：30

作者：

Roudier, C

Auger, I

Roudier, J

机构：

[1] Laboratoire d'Immuno-Rhumatologie, Faculté de Médecine, Univ. de la Mediterranée

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 08期

关键词：

D O I：

10.1016/0167-5699(96)30021-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protein databases have been growing fast, and there has been considerable improvement in the computer software used to explore them. Subsequently, database screening commonly yields evidence of molecular mimicry between unrelated proteins. Here, Chantal Roudier and colleagues analyse the statistical significance of such sequence identities.

引用

页码：357 / 358

页数：2

共 6 条

[1] THE SUSCEPTIBILITY SEQUENCE TO RHEUMATOID-ARTHRITIS IS A CROSS-REACTIVE B-CELL EPITOPE SHARED BY THE ESCHERICHIA-COLI HEAT-SHOCK PROTEIN DNAJ AND THE HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN DRB10401 MOLECULE [J].