Reciprocal Modulation Between TH17 and Other Helper T Cell Lineages

被引:18
作者
Bi, Yujing [1 ]
Liu, Guangwei [2 ]
Yang, Ruifu [1 ]
机构
[1] Acad Mil Med Sci, State Key Lab Pathogen & Biosecur, Army Ctr Microbial Detect & Res, Natl Ctr Biomed Anal,Inst Microbiol & Epidemiol, Beijing 100071, Peoples R China
[2] Chinese Acad Sci, Inst Zool, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
SYSTEMIC-LUPUS-ERYTHEMATOSUS; RETINOIC ACID; ORAL TOLERANCE; DIFFERENTIATION; DISEASE; T(H)17; INHIBITION; PLASTICITY; INDUCTION; PHENOTYPE;
D O I
10.1002/jcp.22331
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
T helper 17 (TH17) cells have well-described roles in autoimmune disease. However, TH17 is not stable in some physiological or pathological courses. Also, TH17 cells can reciprocally modulate and convert into other helper T cell subpopulations. The fully exploring the reciprocal regulatory effects and its immunoregulatory mechanisms are becoming interesting topics in the immunological study. In this review, we summarized reciprocal modulation pattern between TH17 cell and other helper T cell subpopulations in the mouse model of autoimmune diseases and human diseases. J. Cell. Physiol. 226: 8-13, 2010. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码:8 / 13
页数:6
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