Chemistry-to-gene screens in Caenorhabditis elegans

被引：87

作者：

Jones, AK ^{[1
]}

Buckingham, SD ^{[1
]}

Sattelle, DB ^{[1
]}

机构：

[1] Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2005年 / 4卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrd1692

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases.

引用

页码：321 / 330

页数：10

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