Cyclic nucleotide-gated channels -: mediators of NO:cGMP-regulated processes

被引：29

作者：

Biel, M ^{[1
]}

Sautter, A ^{[1
]}

Ludwig, A ^{[1
]}

Hofmann, F ^{[1
]}

Zong, XG ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Pharmakol & Toxikol, D-80802 Munich, Germany

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 1998年 / 358卷 / 01期

关键词：

cyclic nucleotide-gated channels; nitric oxide; cyclic GMP; cyclic AMP; calcium; gene family;

D O I：

10.1007/PL00005235

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cyclic nucleotide-gated (CNG) channels represent one of the three known cellular receptor classes for cGMP. Activation of CNG channels by binding of cyclic nucleotides to a site in the C-terminus results in opening of the channel pore, entry of Ca2+ into the cell and subsequent induction of Ca2+-dependent processes. In this review we will summarize new data on the complex molecular structure and the activation mechanism of CNG channels. In addition, we will discuss the role of CNG channels as mediators of NO:cGMP-dependent cellular processes.

引用

页码：140 / 144

页数：5

共 58 条

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