Segregation of transcription and replication sites into higher order domains

被引：207

作者：

Wei, XY

Samarabandu, J

Devdhar, RS

Siegel, AJ

Acharya, R

Berezney, R ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14260 USA

[2] SUNY Buffalo, Dept Elect & Comp Engn, Buffalo, NY 14260 USA

来源：

SCIENCE | 1998年 / 281卷 / 5382期

关键词：

D O I：

10.1126/science.281.5382.1502

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively, Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.

引用

页码：1502 / 1505

页数：4

共 20 条

[1] MAPPING THE CELLS NUCLEUS [J].