Interactions Between Nuclei and the Cytoskeleton Are Mediated by SUN-KASH Nuclear-Envelope Bridges

被引：431

作者：

Starr, Daniel A. ^{[1
]}

Fridolfsson, Heidi N. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Mol & Cellular Biol, Davis, CA 95616 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 26 | 2010年 / 26卷

关键词：

nuclear positioning; outer nuclear membrane; laminopathies; microtubule motor targeting; Syne; Nesprin; SPINDLE POLE BODY; DREIFUSS MUSCULAR-DYSTROPHY; DOMAIN PROTEINS MSP-300; TAIL-ANCHORED PROTEINS; ACTIN-BINDING PROTEIN; MEMBRANE-PROTEIN; NEURONAL MIGRATION; INTRACELLULAR-TRANSPORT; TRANSMEMBRANE PROTEIN; SPECTRIN SUPERFAMILY;

D O I：

10.1146/annurev-cellbio-100109-104037

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nuclear envelope links the cytoskeleton to structural components of the nucleus. It functions to coordinate nuclear migration and anchorage, organize chromatin, and aid meiotic chromosome pairing. Forces generated by the cytoskeleton are transferred across the nuclear envelope to the nuclear lamina through a nuclear-envelope bridge consisting of SUN (Sad1 and UNC-84) and KASH (Klarsicht, ANC-1 and Syne/Nesprin homology) proteins. Some KASH-SUN combinations connect microtubules, centrosomes, actin filaments, or intermediate filaments to the surface of the nucleus. Other combinations are used in cell cycle control, nuclear import, or apoptosis. Interactions between the cytoskeleton and the nucleus also affect global cytoskeleton organization. SUN and KASH proteins were identified through genetic screens for mispositioned nuclei in model organisms. Knockouts of SUN or KASH proteins disrupt neurological and muscular development in mice. Defects in SUN and KASH proteins have been linked to human diseases including muscular dystrophy, ataxia, progeria, lissencephaly, and cancer.

引用

页码：421 / 444

页数：24

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