Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production

被引：97

作者：

Genc, S ^{[1
]}

Kuralay, F

Genc, K

Akhisaroglu, M

Fadiloglu, S

Yorukoglu, K

Fadiloglu, M

Gure, A

机构：

[1] Dokuz Eylul Univ, Sch Med, Dept Med Biol, TR-35340 Izmir, Turkey

[2] Dokuz Eylul Univ, Sch Med, Dept Biochem, TR-35340 Izmir, Turkey

[3] Dokuz Eylul Univ, Sch Med, Dept Physiol, TR-35340 Izmir, Turkey

[4] Dokuz Eylul Univ, Sch Med, Dept Neurol, TR-35340 Izmir, Turkey

[5] Dokuz Eylul Univ, Sch Med, Dept Pathol, TR-35340 Izmir, Turkey

来源：

NEUROSCIENCE LETTERS | 2001年 / 298卷 / 02期

关键词：

erythropoietin; experimental Parkinsonism; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neuroprotection; nitric oxide; C57/BL;

D O I：

10.1016/S0304-3940(00)01716-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Erythropoietin (EPO), produced by the kidney and fetal liver, is a cytokine-hormone that stimulates erythropoiesis under hypoxic conditions. It has been shown that EPO is produced in the central nervous system and its receptor is expressed on neurons. Since EPO has neuroprotective effects in vitro and in vivo against brain injury, we investigated the effect of EPO treatment on locomotor activities of animals, survival of nigral dopaminergic neurons and nitrate levels in substantia nigra and striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of Parkinsonism in C57/BL mice. Our findings suggest that EPO has protective and treating effect in MPTP-induced neurotoxicity in this mouse model of Parkinson's Disease via increasing nitric oxide production. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：139 / 141

页数：3

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