Cellular signalling:: Stressing the importance of PIP3

被引：16

作者：

Hinchliffe, KA ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0960-9822(01)00197-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipid second messenger PIP3 was previously thought to be generated exclusively by type I PI 3-kinases. Now, a novel route of PIP3 synthesis, controlled by an unrelated enzyme family, has been discovered, increasing our understanding of the versatility of PIP3 in cellular signalling.

引用

页码：R371 / R373

页数：3

共 15 条

[1] PDGF-DEPENDENT TYROSINE PHOSPHORYLATION STIMULATES PRODUCTION OF NOVEL POLYPHOSPHOINOSITIDES IN INTACT-CELLS [J].

AUGER, KR ;

SERUNIAN, LA ;

SOLTOFF, SP ;

LIBBY, P ;

CANTLEY, LC .

CELL, 1989, 57 (01) :167-175

[2] A novel integrin-activated pathway forms PKB/Akt-stimulatory phosphatidylinositol 3,4-bisphosphate via phosphatidylinositol 3-phosphate in platelets [J].

Banfic, H ;

Tang, XW ;

Batty, IH ;

Downes, CP ;

Chen, CS ;

Rittenhouse, SE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (01) :13-16

[3] Biphasic activation of PKBα/Akt in platelets -: Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate [J].

Banfic, H ;

Downes, CP ;

Rittenhouse, SE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (19) :11630-11637

[4] The diversity and possible functions of the inositol polyphosphate 5-phosphatases [J].

Erneux, C ;

Govaerts, C ;

Communi, D ;

Pesesse, X .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1998, 1436 (1-2) :185-199

[5] Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate [J].

Franke, TF ;

Kaplan, DR ;

Cantley, LC ;

Toker, A .

SCIENCE, 1997, 275 (5300) :665-668

[6] A novel pathway of cellular phosphatidylinositol(3,4,5)-trisphosphate synthesis is regulated by oxidative stress [J].

Halstead, JR ;

Roefs, M ;

Ellson, CD ;

D'Andrea, S ;

Chen, CS ;

D'Santos, CS ;

Divecha, N .

CURRENT BIOLOGY, 2001, 11 (06) :386-395

[7] PLATELET-DERIVED GROWTH-FACTOR STIMULATES SYNTHESIS OF PTDLNS(3,4,5)P3 BY ACTIVATING A PTDLNS(4,5)P2 3-OH KINASE [J].

HAWKINS, PT ;

JACKSON, TR ;

STEPHENS, LR .

NATURE, 1992, 358 (6382) :157-159

[8] PIPkins, their substrates and their products: new functions for old enzymes [J].

Hinchliffe, KA ;

Ciruela, A ;

Irvine, RF .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1998, 1436 (1-2) :87-104

[9] The role of phosphoinositide 3-kinase lipid products in cell function [J].

Rameh, LE ;

Cantley, LC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (13) :8347-8350

[10] Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate [J].

Tolias, KF ;

Rameh, LE ;

Ishihara, H ;

Shibasaki, Y ;

Chen, J ;

Prestwich, GD ;

Cantley, LC ;

Carpenter, CL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (29) :18040-18046

← 1 2 →