New silica-immobilized chiral amino alcohol for the enantioselective addition of diethylzinc to benzaldehyde

被引：33

作者：

Fraile, JM

Mayoral, JA ^{[1
]}

Serrano, J

Pericàs, MA

Solà, L

Castellnou, D

机构：

[1] Univ Zaragoza, CSIC, Fac Ciencias, Inst Ciencia Mat Aragon,Dept Quim Organ, E-50009 Zaragoza, Spain

[2] Univ Barcelona, Dept Quim Organ, Unitat Recerca Sintesi Asimetr, E-08028 Barcelona, Spain

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 23期

关键词：

D O I：

10.1021/ol0355985

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A readily available chiral amino alcohol has been immobilized on silica by sol-gel synthesis and grafting. The solid prepared according to the latter method led to the best enantioselectivity (77% ee) described for the asymmetric addition of diethylzinc to benzaldehyde using inorganic solids.

引用

页码：4333 / 4335

页数：3

共 31 条

[1] Direct immobilization of chiral auxiliaries on mineral supports and heterogeneous enantioselective allkylation of benzaldehyde with diethylzinc [J].