Biochemical and biophysical properties of the CO-sensing transcriptional activator CooA

被引：90

作者：

Aono, S ^{[1
]}

机构：

[1] Okazaki Natl Res Inst, Ctr Integrat Biosci, Okazaki, Aichi 4448585, Japan

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2003年 / 36卷 / 11期

关键词：

D O I：

10.1021/ar020097p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Studies of heme-containing gas sensor proteins have revealed a novel function for heme, which acts as an active site for sensing the corresponding gas molecule of a physiological effector. Heme-based O-2, NO, and CO sensor proteins have now been described in which these gas molecules act as a signaling factor that regulates the functional activity of the sensor proteins. CooA is a CO-sensing transcriptional activator found in the photosynthetic bacterium Rhodospirillum rubrum. The binding of CO to the heme group stimulates the transcriptional activator activity of CooA. The mechanisms of CO sensing by CooA and CO-dependent activation of CooA have now been analyzed by both molecular biological and spectroscopic studies and are discussed in this Account.

引用

页码：825 / 831

页数：7

共 47 条

[1]

Agron PG, 1995, 2 COMPONENT SIGNAL T, P275

[2] Single transduction in the transcriptional activator CooA containing a heme-based CO sensor: Isolation of a dominant positive mutant which is active as the transcriptional activator even in the absence of CO [J].

Aono, S ;

Matsuo, T ;

Shimono, T ;

Ohkubo, K ;

Takasaki, H ;

Nakajima, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 240 (03) :783-786

[3] A novel heme protein that acts as a carbon monoxide-dependent transcriptional activator in Rhodospirillum rubrum [J].

Aono, S ;

Nakajima, H ;

Saito, K ;

Okada, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 228 (03) :752-756

[4] Redox-controlled ligand exchange of the heme in the CO-sensing transcriptional activator CooA [J].

Aono, S ;

Ohkubo, K ;

Matsuo, T ;

Nakajima, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) :25757-25764

[5] Resonance Raman and ligand binding studies of the oxygen-sensing signal transducer protein HemAT from Bacillus subtilis [J].

Aono, S ;

Kato, T ;

Matsuki, M ;

Nakajima, H ;

Ohta, T ;

Uchida, T ;

Kitagawa, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (16) :13528-13538

[6] Transcriptional regulation of gene expression by metalloproteins [J].

Aono, S ;

Nakajima, H .

PROGRESS IN REACTION KINETICS AND MECHANISM, 2000, 25 (01) :65-107

[7] CO sensing and regulation of gene expression by the transcriptional activator CooA [J].

Aono, S ;

Honma, Y ;

Ohkubo, K ;

Tawara, T ;

Kamiya, T ;

Nakajima, H .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2000, 82 (1-4) :51-56

[8] Structure and function of CooA, a novel transcriptional regulator containing a b-type heme as a CO sensor [J].

Aono, S ;

Nakajima, H .

COORDINATION CHEMISTRY REVIEWS, 1999, 190 :267-282

[9] Recognition of target DNA and transcription activation by the CO-sensing transcriptional activator CooA [J].

Aono, S ;

Takasaki, H ;

Unno, H ;

Kamiya, T ;

Nakajima, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 261 (02) :270-275

[10]

AONO S, UNPUB

← 1 2 3 4 5 →