Humoral signals mediate the circadian expression of rat period homologue (rPer2) mRNA in peripheral tissues

被引：91

作者：

Oishi, K

Sakamoto, K

Okada, T

Nagase, T

Ishida, N

机构：

[1] MITI, Agcy Ind Sci & Technol, Natl Inst Biosci & Human Technol, Ishida Grp Clock Gene, Tsukuba, Ibaraki 3058566, Japan

[2] Kazusa DNA Res Inst, Chiba, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 256卷 / 02期

关键词：

circadian rhythm; period; peripheral mononuclear leukocyte; humoral factor; suprachiasmatic nucleus; rat; mammal;

D O I：

10.1016/S0304-3940(98)00765-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Northern blot analysis revealed the circadian expression of rat period homologue (rPer2) mRNA in peripheral mononuclear leukocytes that have no neuronal connections. The mRNA expression in the suprachiasmatic nucleus (SCN), peripheral mononuclear leukocytes, and other peripheral tissues exhibited prominent, synchronous circadian oscillation with peaks at early night. As we have previously shown the peripheral circadian expression of rPer2 mRNA is abolished in SCN-lesioned rats [Sakamoto, K., Nagase, T. Fukui, H., Horikawa, K., Okada, T., Tanaka, H., Sate, K., Miyake, Y., Ohara, O., Kako, K. and Ishida, N., J. Biol. Chem., 273 (1998) 27039-27042, our findings suggest that some humoral signals, driven by the SCN, mediate the circadian expression of mammalian per homologues in peripheral tissues. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：117 / 119

页数：3

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