Luteinizing hormone, its β-subunit variant, and epithelial ovarian cancer:: The gonadotropin hypothesis revisited

被引:16
作者
Akhmedkhanov, A
Toniolo, P
Zeleniuch-Jacquotte, A
Pettersson, KS
Huhtaniemi, IT
机构
[1] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Environm Med, New York, NY 10016 USA
[3] Univ Turku, Dept Biotechnol, SF-20500 Turku, Finland
[4] Univ Turku, Dept Physiol, SF-20500 Turku, Finland
关键词
gonadotropins; LH; ovarian neoplasms; polymorphism (genetics);
D O I
10.1093/aje/154.1.43
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The gonadotropin hypothesis postulates that excessive gonadotropin stimulation results in increased proliferation and subsequent malignant transformation of ovarian epithelium. The authors evaluated this hypothesis by analyzing the association between serum levels of wild-type luteinizing hormone (LH) and ovarian cancer risk. They also examined the relation between a variant of LH containing two missense point mutations (Trp(8)Arg and lle(15)Thr) in its beta -subunit and ovarian cancer risk. Fifty-eight cases of epithelial ovarian cancer and 116 controls matched on age, menopausal status, and date of blood donation were included in a case-control study nested within the New York University Women's Health Study, a prospective cohort enrolled between 1985 and 1991 in New York City, Wild-type serum levels and Variant LH status were determined by immunofluorometric assays in which monoclonal antibodies specific for wild-type and variant LH were used. Compared with women in the lowest tertile of wild-type LH, women in the highest tertile had a lower risk of ovarian cancer, after adjustment for potential confounders (odds ratio = 0.42, 95% confidence interval: 0.09, 2.09). Women heterozygous for variant LH were not at increased risk (adjusted odds ratio = 0.95, 95% confidence interval: 0.27, 3.34). The results suggest that neither wild-type LH levels nor variant LH status is associated with increased risk of epithelial ovarian cancer.
引用
收藏
页码:43 / 49
页数:7
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