Excellent cognitive performance despite massive cerebral white matter changes

被引：14

作者：

Duning, T

Kugel, H

Knecht, S

机构：

[1] Univ Munster, Dept Neurol, D-48129 Munster, Germany

[2] Univ Munster, Dept Clin Radiol, D-4400 Munster, Germany

[3] Univ Munster, IZKF Munster, D-4400 Munster, Germany

来源：

NEURORADIOLOGY | 2005年 / 47卷 / 10期

关键词：

white matter changes; cognitive impairment; leuko-araiosis; cognitive reserve; neuropsychological testing;

D O I：

10.1007/s00234-005-1420-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Marked cerebral white matter changes are a frequent finding in the daily routine of magnetic resonance imaging of elderly patients. These findings are often equated with a decrease of cognitive function. Here we present a case of massive white matter changes but excellent cognitive performance, to avoid the automatism of drawing conclusions on intellectual ability by just interpreting the imaging data of elderly patients.

引用

收藏

页码：749 / 752

页数：4

相关论文

共 23 条

[1]

From social integration to health: Durkheim in the new millennium [J].

Berkman, LF ;

Glass, T ;

Brissette, I ;

Seeman, TE .

SOCIAL SCIENCE & MEDICINE, 2000, 51 (06) :843-857

[2]

CEREBRAL WHITE-MATTER LESIONS, VASCULAR RISK-FACTORS, AND COGNITIVE FUNCTION IN A POPULATION-BASED STUDY - THE ROTTERDAM STUDY [J].

BRETELER, MMB ;

VANSWIETEN, JC ;

BOTS, ML ;

GROBBEE, DE ;

CLAUS, JJ ;

VANDENHOUT, JHW ;

VANHARSKAMP, F ;

TANGHE, HLJ ;

DEJONG, PTVM ;

VANGIJN, J ;

HOFMAN, A .

NEUROLOGY, 1994, 44 (07) :1246-1252

[3]

Exercise, experience and the aging brain [J].

Churchill, JD ;

Galvez, R ;

Colcombe, S ;

Swain, RA ;

Kramer, AF ;

Greenough, WT .

NEUROBIOLOGY OF AGING, 2002, 23 (05) :941-955

[4]

Periventricular cerebral white matter lesions predict rate of cognitive decline [J].

de Groot, JC ;

de Leeuw, FE ;

Oudkerk, M ;

van Gijn, J ;

Hofman, A ;

Jolles, J ;

Breteler, MMB .

ANNALS OF NEUROLOGY, 2002, 52 (03) :335-341

[5]

Achieving and maintaining cognitive vitality with aging [J].

Fillit, HM ;

Butler, RN ;

O'Connell, AW ;

Albert, MS ;

Birren, JE ;

Cotman, CW ;

Greenough, WT ;

Gold, PE ;

Kramer, AF ;

Kuller, LH ;

Perls, TT ;

Sahagan, BG ;

Tully, T .

MAYO CLINIC PROCEEDINGS, 2002, 77 (07) :681-696

[6]

An active and socially integrated lifestyle in late life might protect against dementia [J].

Fratiglioni, L ;

Paillard-Borg, S ;

Winblad, B .

LANCET NEUROLOGY, 2004, 3 (06) :343-353

[7]

Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study [J].

Garde, E ;

Mortensen, EL ;

Krabbe, K ;

Rostrup, E ;

Larsson, HBW .

LANCET, 2000, 356 (9230) :628-634

[8]

LEUKOARAIOSIS [J].

HACHINSKI, VC ;

POTTER, P ;

MERSKEY, H .

ARCHIVES OF NEUROLOGY, 1987, 44 (01) :21-23

[9]

Helmstaedter C, 1990, Schweiz Arch Neurol Psychiatr (1985), V141, P21

[10]

Splice site mutation causing a seven amino acid Notch3 in-frame deletion in CADASIL [J].

Joutel, A ;

Chabriat, H ;

Vahedi, K ;

Domenga, V ;

Vayssière, C ;

Ruchoux, MM ;

Lucas, C ;

Leys, D ;

Bousser, MG ;

Tournier-Lasserve, E .

NEUROLOGY, 2000, 54 (09) :1874-1875