Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum

被引：21

作者：

Suksamrarn, A ^{[1
]}

Buaprom, M

Udtip, S

Nuntawong, N

Haritakun, R

Kanokmedhakul, S

机构：

[1] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok 10240, Thailand

[2] Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand

[3] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Pathum Thani 12120, Thailand

[4] Khon Kaen Univ, Fac Sci, Dept Chem, Khon Kaen 40002, Thailand

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 10期

关键词：

Scleropyrum wallichianum; scleropyric acid; beta-sitosteryl-3-O-scleropyrate; stiginasteryl-3-O-scleropyrate; anti-mycobacterial activity; antiplasmodial activity;

D O I：

10.1248/cpb.53.1327

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two 14 new esters, beta-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, beta-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 mu g/ml and showed antiplasmodial activity with an IC50 value of 7.2 mu g/ml. Compounds 2 and 3 were inactive in both assays.

引用

页码：1327 / 1329

页数：3

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