Mechanotransduction in striated muscle via focal adhesion kinase

被引：28

作者：

Durieux, A. C.

Desplanches, D.

Freyssenet, D.

Flueck, M. ^{[1
]}

机构：

[1] Univ Bern, Dept Anat, CH-3000 Bern, Switzerland

[2] Univ Lyon 1, Lab Integrat Cellular & Mol Physiol, CNRS, F-6922 Villeurbanne, France

[3] Univ St Etienne, Lab Physiol & Physiopathol Exercise & Handicap, St Etienne, France

[4] Manchester Metropolitan Univ, Inst Biophys & Clin Res Human Movement, Stoke On Trent ST7 2HL, Staffs, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷

关键词：

focal adhesion kinase (FAK); mechanobiology; mechanotransduction; phosphorylation; striated muscle;

D O I：

10.1042/BST0351312

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Contractile tissues demonstrate a pronounced capacity to remodel their composition in response to mechanical challenges. Descriptive evidence suggests the upstream involvement of the phosphortransfer enzyme FAK (focal adhesion kinase) in the molecular control of load-dependent muscle plasticity. Thereby FAK evolves as a myocellular transducer of mechanical signals towards downstream transcript expression in myofibres. Recent advances in somatic gene therapy now allow the exploration of the functional involvement of this enzyme in mechanotransduction in intact muscle.

引用

页码：1312 / 1313

页数：2

共 16 条

[1] MOLECULAR AND CELLULAR ADAPTATION OF MUSCLE IN RESPONSE TO EXERCISE - PERSPECTIVES OF VARIOUS MODELS [J].