The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

被引：160

作者：

Wolf, DA ^{[1
]}

Zhou, CS ^{[1
]}

Wee, S ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 12期

关键词：

D O I：

10.1038/ncb1203-1029

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The COP9 signalosome (CSN) is a highly conserved protein complex implicated in diverse biological functions that involve ubiquitin-mediated proteolysis. Paradoxically, conserved enzymatic activities associated with CSN inhibit cullin ubiquitin ligase activity in vitro, whereas mutational analysis suggests that CSN promotes cullin-dependent proteolysis in vivo. This apparent paradox can be resolved in a model that proposes CSN-mediated cullin inhibition is a prerequisite for the proper assembly and maintenance of active cullin ubiquitin ligase complexes.

引用

页码：1029 / 1033

页数：5

共 51 条

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