5-hydroxylapachol:: A cytotoxic agent from Tectona grandis

被引：50

作者：

Khan, RM ^{[1
]}

Mlungwana, SM

机构：

[1] PNG Univ Technol, Dept Appl Sci, Lae, Papua N Guinea

[2] Univ Dar Es Salaam, Dept Chem, Dar Es Salaam, Tanzania

来源：

PHYTOCHEMISTRY | 1999年 / 50卷 / 03期

关键词：

Tectona grandis; verbenaceae; naphthoquinones; 5-hydroxylapachol; lapachol; dehydro-alpha-lapachone; methylquinizarin; squalene; cytotoxicity;

D O I：

10.1016/S0031-9422(98)00478-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

From the root heart wood of Tectona grandis were isolated a new compound, 5-hydroxylapachol (1) along with the known constituents lapachol, dehydro-alpha-lapachone, methylquinizarin and squalene. Both compound 1 and lapachol were found to be cytotoxic to Artemia salina (brine shrimp) with an LC50 of 5 ppm. The structure of compound 1 has been elucidated on the basis of its spectral data, mainly, H-1 and C-13 NMR. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：439 / 442

页数：4

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