Default Mode Network Connectivity Predicts Sustained Attention Deficits after Traumatic Brain Injury

被引:369
作者
Bonnelle, Valerie [1 ,2 ]
Leech, Robert [1 ]
Kinnunen, Kirsi M. [3 ]
Ham, Tim E. [1 ]
Beckmann, Cristian F. [1 ,4 ]
De Boissezon, Xavier [5 ,6 ,7 ]
Greenwood, Richard J. [8 ]
Sharp, David J. [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Computat Cognit & Clin Neuroimaging Lab, Ctr Neurosci, Div Expt Med, London W12 0NN, England
[2] Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, London W12 0NN, England
[3] Univ London, London SE14 6NW, England
[4] Univ Twente, MIRA Inst Biomed Technol & Tech Med, NL-6500 HB Nijmegen, Netherlands
[5] INSERM, Imagerie Cerebrale & Handicaps Neurol UMR 825, F-31059 Toulouse, France
[6] Univ Toulouse, UPS, Imagerie Cerebrale & Handicaps Neurol UMR 825, CHU Purpan, F-31059 Toulouse 9, France
[7] CHU Purpan, Ctr Hosp Univ Toulouse, F-31059 Toulouse 9, France
[8] UCL, Inst Neurol, London WC1N 3BG, England
基金
英国医学研究理事会;
关键词
INDEPENDENT COMPONENT ANALYSIS; STATE FUNCTIONAL CONNECTIVITY; POSTERIOR CINGULATE CORTEX; WORKING-MEMORY; VIGILANCE DECREMENT; COGNITIVE CONTROL; WANDERING MINDS; REACTION-TIME; HEAD-INJURY; TASK;
D O I
10.1523/JNEUROSCI.1163-11.2011
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Traumatic brain injury (TBI) frequently produces impairments of attention in humans. These can result in a failure to maintain consistent goal-directed behavior. A predominantly right-lateralized frontoparietal network is often engaged during attentionally demanding tasks. However, lapses of attention have also been associated with increases in activation within the default mode network (DMN). Here, we study TBI patients with sustained attention impairment, defined on the basis of the consistency of their behavioral performance over time. We show that sustained attention impairments in patients are associated with an increase in DMN activation, particularly within the precuneus and posterior cingulate cortex. Furthermore, the interaction of the precuneus with the rest of the DMN at the start of the task, i.e., its functional connectivity, predicts which patients go on to show impairments of attention. Importantly, this predictive information is present before any behavioral evidence of sustained attention impairment, and the relationship is also found in a subgroup of patients without focal brain damage. TBI often results in diffuse axonal injury, which produces cognitive impairment by disconnecting nodes in distributed brain networks. Using diffusion tensor imaging, we demonstrate that structural disconnection within the DMN also correlates with the level of sustained attention. These results show that abnormalities in DMN function are a sensitive marker of impairments of attention and suggest that changes in connectivity within the DMN are central to the development of attentional impairment after TBI.
引用
收藏
页码:13442 / 13451
页数:10
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