Regiospecific synthesis of 3-substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, and imidazo[1,2-c]pyrimidine

被引：160

作者：

Katritzky, AR ^{[1
]}

Xu, YJ ^{[1
]}

Tu, HB ^{[1
]}

机构：

[1] Univ Florida, Ctr Heterocycl Chem, Dept Chem, Gainesville, FL 32611 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 12期

关键词：

D O I：

10.1021/jo026797p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, and imidazo[1,2-c]pyrimidine were obtained regiospecifically in yields of 35-92% in one pot by reaction of 2-aminopyridines or 2-(or 4-)aminopyrimidines, respectively, with 1,2-bis(benzotriazolyl)-1,2-(dialkylamino)-ethanes.

引用

页码：4935 / 4937

页数：3

共 38 条

[1] A novel class of orally active non-peptide bradykinin B2 receptor antagonists.: 1.: Construction of the basic framework [J].

Abe, Y ;

Kayakiri, H ;

Satoh, S ;

Inoue, T ;

Sawada, Y ;

Imai, K ;

Inamura, N ;

Asano, M ;

Hatori, C ;

Katayama, A ;

Oku, T ;

Tanaka, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (04) :564-578

[2]

Abignente E., 1985, REND ATTI ACCAD SCI, V139, P313

[3]

Abignente E., 1991, Actualites de Chimie Therapeutique, V18, P193

[4] DERIVATIVES OF IMIDAZOLE .I. SYNTHESIS AND REACTIONS OF IMIDAZO[1,2-A]PYRIDIENES WITH ANALGESIC ANTIINFLAMMATORY ANTIPYRETIC AND ANTICONVULSANT ACTIVITY [J].

ALMIRANTE, L ;

POLO, L ;

MUGNAINI, A ;

PROVINCIALI, E ;

RUGARLI, P ;

BIANCOTTI, A ;

GAMBA, A ;

MURMANN, W .

JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (03) :305-+

[5]

ASTIK RR, 1981, J INDIAN CHEM SOC, V58, P1013

[6]

BARTEL PL, 1993, CLONTECHNIQUES, V8, P1

[7] ISOMERIC PHENYLTHIOIMIDAZO[1,2-A]PYRIDINES AS ANTHELMINTICS [J].

BOCHIS, RJ ;

OLEN, LE ;

FISHER, MH ;

REAMER, RA ;

WILKS, G ;

TAYLOR, JE ;

OLSON, G .

JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (12) :1483-1487

[8] MESO-IONIC COMPOUNDS DERIVED FROM PYRIDINO(1'-2'-1-2)GLYOXALINE [J].

BRISTOW, NW ;

CHARLTON, PT ;

PEAK, DA ;

SHORT, WF .

JOURNAL OF THE CHEMICAL SOCIETY, 1954, (FEB) :616-629

[9] Heterocyclization of functionalized vinylic derivatives of imidazo[1,2-α]pyridines [J].

Chezal, JM ;

Moreau, E ;

Delmas, G ;

Gueiffier, A ;

Blache, Y ;

Grassy, G ;

Lartigue, C ;

Chavignon, O ;

Teulade, JC .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (20) :6576-6584

[10] SYNTHESIS AND ANTIVIRAL ACTIVITY OF 3-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES [J].

ELHAKMAOUI, A ;

GUEIFFIER, A ;

MILHAVET, JC ;

BLACHE, Y ;

CHAPAT, JP ;

CHAVIGNON, O ;

TEULADE, JC ;

SNOECK, R ;

ANDREI, G ;

DECLERCQ, E .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (16) :1937-1940

← 1 2 3 4 →