MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus

被引：27

作者：

Lang, Karl S.

Navarini, Alexander A.

Recher, Mike

Lang, Philipp A.

Heikenwalder, Mathias

Stecher, Barbara

Bergthaler, Andreas

Odermatt, Bernhard

Akira, Shizuo

Honda, Kenya

Hengartner, Hans

Zinkernagel, Rolf M.

机构：

[1] Univ Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland

[2] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

[3] Univ Zurich Hosp, Inst Surg Pathol, CH-8091 Zurich, Switzerland

[4] ETH, Inst Microbiol, CH-8092 Zurich, Switzerland

[5] Osaka Univ, Res Inst Microbial Dis, Dept Host Def, Osaka, Japan

[6] Univ Tokyo, Grad Sch Med, Dept Immunol, Tokyo, Japan

[7] Univ Tokyo, Fac Med, Tokyo 113, Japan

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2007年 / 37卷 / 09期

关键词：

inflammation; toll-like receptor; vesicular stomatitis virus;

D O I：

10.1002/eji.200737310

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88(-/-) mice. We found an increased susceptibility to VSV in myd88(-/-) mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88(-/-) mice correlated with impaired recruitment of immune cells to the site of infection. In the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis.

引用

页码：2434 / 2440

页数：7

共 25 条

[1] Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function [J].