1,4-bis(arylsulfonyl)dihydropyridines in synthesis. Enantioselective synthesis of 2,3,6-trisubstituted piperidines

被引：4

作者：

Carballares, S ^{[1
]}

Craig, D ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, Ctr Chem Synthesis, London SW7 2AY, England

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2001年 / 624卷 / 1-2期

关键词：

2,3,6-trisubstituted piperidines; enantioselective synthesis; organolithium;

D O I：

10.1016/S0022-328X(00)00918-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A 2-substituted 1,4-bis (4-tolylsulfonyl)-1,2-dihydropyridine is readily accessed from an alpha -aminoester and 1,1-dimethoxy-3-(4-tolylsulfonyl)propane. This cyclic diene enters into highly selective addition reactions with carbon nucleophiles, and the product of one of these transformations is converted into a 2,3,6-trisubstituted piperidine via an S(N)1 ' reaction. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：380 / 382

页数：3

共 7 条

[1]

Adelbrecht JC, 2000, SYNLETT, P467

[2]

ADELBRECHT JC, UNPUB

[3] Versatile and stereoselective synthesis of diamino diol dipeptide isosteres, core units of pseudopeptide HIV protease inhibitors [J].