Novel therapeutic approaches in IBS

被引：16

作者：

Bradesi, Sylvie ^{[1
,4
]}

Mayer, Emeran A. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, UCLA Ctr Neurovisceral Sci & Womens Hlth, David Geffen Sch Med, Dept Med, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, UCLA Ctr Neurovisceral Sci & Womens Hlth, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, UCLA Ctr Neurovisceral Sci & Womens Hlth, David Geffen Sch Med, Dept Psychiat, Los Angeles, CA 90024 USA

[4] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2007年 / 7卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.coph.2007.09.012

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Irritable bowel syndrome (IBS) remains an incompletely understood, common syndrome with significant unmet medical needs. Significant progress has been made in the development of novel therapies aimed at normalizing bowel habit alterations and abdominal discomfort, even though some of the most effective treatments are currently only available for patients under a restricted access program from the FDA. Preclinical evidence supports the potential usefulness of several compounds in development for the treatment of chronic abdominal pain. Recent new evidence for a possible role of altered microflora and altered host microbial interactions may provide new treatment targets in the future.

引用

收藏

页码：598 / 604

页数：7

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