Mast cells: A possible link between psychological stress, enteric infection, food allergy and gut hypersensitivity in the Irritable Bowel syndrome

被引：50

作者：

Gui, XY ^{[1
]}

机构：

[1] Univ Sydney, Royal N Shore Hosp, Dept Med, Gastrointestinal Unit, St Leonards, NSW 2065, Australia

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 1998年 / 13卷 / 10期

关键词：

functional bowel disorder; hypersensitivity; Irritable Bowel syndrome; irritable gut; mast cell;

D O I：

10.1111/j.1440-1746.1998.tb00558.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Intestinal mast cell activation (degranulation), which results fi om previous enteric infection and/or intestinal allergy, may play a central role in the gut hypersensitivity in both motor response and visceral perception in the Irritable Bowel syndrome. This occurs through various mediators acting on enteric neurons and smooth muscle cells. Psychological stress may trigger this sensitive alarm system via the brain-gut axis.

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收藏

页码：980 / 989

页数：10

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