Osteoblast and osteoclast activity in a malignant infantile osteopetrosis patient following bone marrow transplantation

被引：33

作者：

Chen, CJ

Chao, TY

Chu, DM

Janckila, AI

Cheng, SN

机构：

[1] Tri Serv Gen Hosp, Dept Pediat, Natl Def Med Ctr, Taipei 114, Taiwan

[2] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Med, Taipei 114, Taiwan

[3] Vet Affairs Med Ctr, Special Hematol Lab, Louisville, KY USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2004年 / 26卷 / 01期

关键词：

bone marrow transplantation; bone-specific alkaline; phosphatase; malignant infantile osteopetrosis; tartrate-resistant acid; 5b; children;

D O I：

10.1097/00043426-200401000-00003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation. The patient's clinical response was compared with his biochemical response for bone metabolic markers such as tartrate-resistant acid phosphatase 5b (TRAcP 5b) and bone-specific alkaline phosphatase (BAP). Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation.

引用

页码：5 / 8

页数：4

共 18 条

[1] Chloride channel 7 (CLCN7) gene mutations in intermediate autosomal recessive osteopetrosis [J].