Composition and functional role of the mucus layers in the intestine

被引：400

作者：

Johansson, Malin E. V. ^{[1
]}

Ambort, Daniel ^{[1
]}

Pelaseyed, Thaher ^{[1
]}

Schutte, Andre ^{[1
]}

Gustafsson, Jenny K. ^{[1
]}

Ermund, Anna ^{[1
]}

Subramani, Durai B. ^{[1
]}

Holmen-Larsson, Jessica M. ^{[1
]}

Thomsson, Kristina A. ^{[1
]}

Bergstrom, Joakim H. ^{[1
]}

van der Post, Sjoerd ^{[1
]}

Rodriguez-Pineiro, Ana M. ^{[1
]}

Sjovall, Henrik ^{[1
]}

Backstrom, Malin ^{[1
]}

Hansson, Gunnar C. ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Med Biochem, S-40530 Gothenburg, Sweden

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2011年 / 68卷 / 22期

基金：

瑞典研究理事会;

关键词：

Mucus; Mucin; MUC2; Colon; Commensal bacteria; Small intestine; NIPPOSTRONGYLUS-BRASILIENSIS; O-GLYCOSYLATION; C-TERMINUS; MUCIN; PROTEIN; COMPLEX; COLON; MEMBRANE; IDENTIFICATION; INFECTION;

D O I：

10.1007/s00018-011-0822-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In discussions on intestinal protection, the protective capacity of mucus has not been very much considered. The progress in the last years in understanding the molecular nature of mucins, the main building blocks of mucus, has, however, changed this. The intestinal enterocytes have their apical surfaces covered by transmembrane mucins and the whole intestinal surface is further covered by mucus, built around the gel-forming mucin MUC2. The mucus of the small intestine has only one layer, whereas the large intestine has a two-layered mucus where the inner, attached layer has a protective function for the intestine, as it is impermeable to the luminal bacteria.

引用

页码：3635 / 3641

页数：7

共 35 条

[1] Function of the CysD domain of the gel-forming MUC2 mucin [J].

Ambort, Daniel ;

van der Post, Sjoerd ;

Johansson, Malin E. V. ;

MacKenzie, Jenny ;

Thomsson, Elisabeth ;

Krengel, Ute ;

Hansson, Gunnar C. .

BIOCHEMICAL JOURNAL, 2011, 436 :61-70

[2] The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo [J].

Atuma, C ;

Strugala, V ;

Allen, A ;

Holm, L .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 280 (05) :G922-G929

[3] O-glycosylated MUC2 monomer and dimer from LS 174T cells are water-soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds [J].

Axelsson, MAB ;

Asker, N ;

Hansson, GC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (30) :18864-18870

[4] Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins [J].

Axelsson, MAB ;

Karlsson, NG ;

Steel, DM ;

Ouwendijk, J ;

Nilsson, T ;

Hansson, GC .

GLYCOBIOLOGY, 2001, 11 (08) :633-644

[5]

CARLSTEDT I, 1993, J BIOL CHEM, V268, P18771

[6] Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice [J].

Fu, Jianxin ;

Wei, Bo ;

Wen, Tao ;

Johansson, Malin E. V. ;

Liu, Xiaowei ;

Bradford, Emily ;

Thomsson, Kristina A. ;

McGee, Samuel ;

Mansour, Lilah ;

Tong, Maomeng ;

McDaniel, J. Michael ;

Sferra, Thomas J. ;

Turner, Jerrold R. ;

Chen, Hong ;

Hansson, Gunnar C. ;

Braun, Jonathan ;

Xia, Lijun .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (04) :1657-1666

[7] Evolutionary considerations in relating oligosaccharide diversity to biological function [J].

Gagneux, P ;

Varki, A .

GLYCOBIOLOGY, 1999, 9 (08) :747-755

[8] The future of mucosal immunology: studying an integrated system-wide organ [J].

Gill, Navkiran ;

Wlodarska, Marta ;

Finlay, B. Brett .

NATURE IMMUNOLOGY, 2010, 11 (07) :558-560

[9] The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment [J].

Godl, K ;

Johansson, MEV ;

Lidell, ME ;

Mörgelin, M ;

Karlsson, H ;

Olson, FJ ;

Gum, JR ;

Kim, YS ;

Hansson, GC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (49) :47248-47256

[10]

Hansson G C, 1988, Adv Exp Med Biol, V228, P465

← 1 2 3 4 →