Magnetic Nanocarriers with Tunable pH Dependence for Controlled Loading and Release of Cationic and Anionic Payloads

被引：41

作者：

Bigall, Nadja C. ^{[1
]}

Curcio, Alberto ^{[1
]}

Leal, Manuel Pernia ^{[1
]}

Falqui, Andrea ^{[1
]}

Palumberi, Domenico ^{[1
]}

Di Corato, Riccardo ^{[1
,2
]}

Albanesi, Ennio ^{[1
]}

Cingolani, Roberto ^{[1
]}

Pellegrino, Teresa ^{[1
,2
]}

机构：

[1] Ist Italiano Tecnol, I-16163 Genoa, Italy

[2] CNR, Nanosci Inst, Natl Nanotechnol Lab, I-73100 Lecce, Italy

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 47期

关键词：

superparamagnetic nanocarriers; pH-responsive materials; gold nanoparticles; magnetic nanobeads; siRNA delivery; NANOPARTICLE DESIGN; SIRNA DELIVERY; DRUG-DELIVERY; POLYMER; NANOCRYSTALS; THERAPY;

D O I：

10.1002/adma.201103505

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.

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收藏

页码：5645 / +

页数：7

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