Reduction of regional cerebral blood flow and cognitive impairment in patients with Alzheimer's disease: Evaluation of an observer-independent analytic approach

被引:41
作者
Hirsch, C
Bartenstein, P
Minoshima, S
Mosch, D
Willoch, F
Buch, K
Schad, D
Schwaiger, M
Kurz, A
机构
[1] TECH UNIV MUNICH, DEPT NUCL MED, D-8000 MUNICH, GERMANY
[2] TECH UNIV MUNICH, DEPT PSYCHIAT, D-8000 MUNICH, GERMANY
[3] UNIV MICHIGAN, DIV NUCL MED, ANN ARBOR, MI 48109 USA
关键词
single-photon emission computed tomography; Alzheimer's disease; cognitive dysfunction; three-dimensional display;
D O I
10.1159/000106613
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The aim of the study was to evaluate an observer-independent semiquantitative analysis of brain imaging by single-photon emission computed tomography (SPECT) in patients with Alzheimer's disease (AD). Patients (n = 45, mean age 70 +/- 11 years) with a clinical diagnosis of AD according to NINCDS/ADRDA criteria were examined by Tc-99m-ethylcysteine dimer SPECT. Following anatomic normalization and data extraction using three-dimensional stereotactic surface projection, a pixelwise comparison of ECD uptake was performed with the reference values of 10 cognitive intact controls of comparable age. The global relative decrease of cerebral blood flow in cortical association areas showed a significant inverse association with the overall level of cognitive functioning as assessed with the Mini Mental State Examination and with the cognitive section (CAMCOG) of the Cambridge Mental Disorders of the Elderly Examination. There were significant region-specific associations between left temporoparietal perfusion deficit and language performance and between right temporoparietal regional cerebral blood flow reduction and praxis. The results suggest that this observer-independent analysis of SPECT data provides a valid assessment of the pattern and severity of cortical perfusion abnormalities in patients with AD..
引用
收藏
页码:98 / 104
页数:7
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