Multiple endocrine neoplasia type 1 associated with spinal ependymoma

被引：36

作者：

Kato, H

Uchimura, I

Morohoshi, M

Fujisawa, K

Kobayashi, Y

Numano, F

Goseki, N

Endo, M

Tamura, A

Nagashima, C

机构：

[1] Third Dept. of Internal Medicine, School of Medicine, Tokyo Medical and Dental University, Tokyo

[2] First Department of Surgery, School of Medicine, Tokyo Medical and Dental University, Tokyo

[3] Department of Pathology, School of Medicine, Tokyo Medical and Dental University, Tokyo

[4] Department of Neurosurgery, Saitama Medical School

[5] Third Dept. of Internal Medicine, School of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113

来源：

INTERNAL MEDICINE | 1996年 / 35卷 / 04期

关键词：

11q13; hyperparathyroidism; insulinoma; pancreatic tumor; pituitary adenoma;

D O I：

10.2169/internalmedicine.35.285

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 51-year-old man was hospitalized with a gait disturbance and hypoesthesia below the level of his chest. These symptoms were due to a spinal tumor which was surgically resected and identified as an ependymoma. Additionally, the patient had hypercalcemia and a family history of insulinoma. An endocrine evaluation revealed parathyroid hyperplasia and a pancreatic islet cell tumor. Magnetic resonance imaging disclosed a pituitary microadenoma. He was diagnosed with spinal ependymoma and multiple endocrine neoplasia type 1 (MEN 1). A review of the literature revealed that chromosome 11q13 abnormalities have been reported in both ependymoma and MEN 1. We discuss the pathogenesis of these diseases.

引用

页码：285 / 289

页数：5

共 19 条

[1] DNA-SEQUENCES SIMILAR TO THOSE OF SIMIAN VIRUS-40 IN EPENDYMOMAS AND CHOROID-PLEXUS TUMORS OF CHILDHOOD [J].